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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CHEK2
All Species:
36.67
Human Site:
T378
Identified Species:
57.62
UniProt:
O96017
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O96017
NP_001005735.1
543
60915
T378
H
S
K
I
L
G
E
T
S
L
M
R
T
L
C
Chimpanzee
Pan troglodytes
XP_001172779
543
60866
T378
H
S
K
I
L
G
E
T
S
L
M
R
T
L
C
Rhesus Macaque
Macaca mulatta
XP_001102484
543
60923
T378
H
S
K
I
L
G
E
T
S
L
M
R
T
L
C
Dog
Lupus familis
XP_543464
544
61233
T379
Q
S
K
I
L
G
E
T
S
L
M
R
T
L
C
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z265
546
61070
T382
Q
S
K
I
L
G
E
T
S
L
M
R
T
L
C
Rat
Rattus norvegicus
NP_446129
545
60912
T381
Q
S
K
I
L
G
E
T
S
L
M
R
T
L
C
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508699
537
60493
T356
Q
S
K
I
L
G
E
T
S
L
M
R
T
L
C
Chicken
Gallus gallus
NP_001073576
522
58779
T355
Q
S
K
I
L
G
E
T
S
L
M
K
T
L
C
Frog
Xenopus laevis
NP_001082016
517
58243
T350
Q
S
K
I
L
G
E
T
S
L
M
R
T
L
C
Zebra Danio
Brachydanio rerio
Q501V0
422
47914
Y272
E
I
L
V
R
K
P
Y
T
N
A
V
D
M
W
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O61267
476
54243
L327
L
K
V
S
D
F
G
L
S
K
F
V
Q
K
D
Honey Bee
Apis mellifera
XP_624334
480
54300
C331
Q
T
M
M
K
T
F
C
G
T
P
M
Y
V
A
Nematode Worm
Caenorhab. elegans
Q9U1Y5
476
53320
K327
L
T
D
F
G
M
A
K
N
S
V
N
R
M
K
Sea Urchin
Strong. purpuratus
XP_794585
480
52849
S330
S
K
F
V
G
E
Q
S
L
M
K
T
L
C
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P39009
513
58614
I359
W
D
E
D
E
I
D
I
Q
V
K
I
A
D
F
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
99
89.3
N.A.
83.1
83.4
N.A.
74.4
67.5
59.6
28.1
N.A.
34
37.2
30.2
43.2
Protein Similarity:
100
99.8
99
93
N.A.
89.7
89.9
N.A.
82.1
77.9
73.1
41.9
N.A.
51.5
54.5
49.5
58.3
P-Site Identity:
100
100
100
93.3
N.A.
93.3
93.3
N.A.
93.3
86.6
93.3
0
N.A.
6.6
0
0
0
P-Site Similarity:
100
100
100
93.3
N.A.
93.3
93.3
N.A.
93.3
93.3
93.3
20
N.A.
6.6
20
26.6
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
28.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
47.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
7
0
0
0
7
0
7
0
7
% A
% Cys:
0
0
0
0
0
0
0
7
0
0
0
0
0
7
60
% C
% Asp:
0
7
7
7
7
0
7
0
0
0
0
0
7
7
7
% D
% Glu:
7
0
7
0
7
7
60
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
7
7
0
7
7
0
0
0
7
0
0
0
7
% F
% Gly:
0
0
0
0
14
60
7
0
7
0
0
0
0
0
7
% G
% His:
20
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
7
0
60
0
7
0
7
0
0
0
7
0
0
0
% I
% Lys:
0
14
60
0
7
7
0
7
0
7
14
7
0
7
7
% K
% Leu:
14
0
7
0
60
0
0
7
7
60
0
0
7
60
0
% L
% Met:
0
0
7
7
0
7
0
0
0
7
60
7
0
14
0
% M
% Asn:
0
0
0
0
0
0
0
0
7
7
0
7
0
0
0
% N
% Pro:
0
0
0
0
0
0
7
0
0
0
7
0
0
0
0
% P
% Gln:
47
0
0
0
0
0
7
0
7
0
0
0
7
0
0
% Q
% Arg:
0
0
0
0
7
0
0
0
0
0
0
54
7
0
0
% R
% Ser:
7
60
0
7
0
0
0
7
67
7
0
0
0
0
0
% S
% Thr:
0
14
0
0
0
7
0
60
7
7
0
7
60
0
0
% T
% Val:
0
0
7
14
0
0
0
0
0
7
7
14
0
7
0
% V
% Trp:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% W
% Tyr:
0
0
0
0
0
0
0
7
0
0
0
0
7
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _